Thank you @zentry team for Nexus Reward, I saw a couple rewards from each project $ZENT $CAG $RON $BEAM send to my wallet. So happy. Everyone check your wallet that you connected to Nexus. Merry Christmas 🎄🎁

$NTLA $PRME $BEAM $CRSP

@levolev It varies weekly but I’d say today: 35% $NTLA 35% $PRME 20% $BEAM 10% $CRSP

🧬 25 Cool Gene Editing Facts $NTLA $PRME $BEAM $CRSP 1️⃣ CRISPR isn’t a drug — it’s a molecular GPS + scissors, originally evolved by bacteria to fight viruses. 2️⃣ The first FDA-approved CRISPR therapy (Casgevy-Dec. 2023) edits cells ex vivo (outside the body) and can permanently cure sickle cell disease and beta thalassemia. 3️⃣ In vivo CRISPR means editing genes inside the body— the Magnitude ATTR-CM trial is the largest in history (n=1200). 4️⃣ The human liver is the most edited organ in medicine because it naturally absorbs lipid nanoparticles. 5️⃣ One-and-done gene editing means no chronic dosing, no accumulation, no compliance issues. 6️⃣ Base editing and prime editing can change a single DNA letter without cutting the DNA double helix. 7️⃣ Prime editing (PE) is sometimes called CRISPR 3.0— it can make precise edits and has the potential to correct more genes than any other technology. PE has cured 2 CGD patients and will show first in vivo human data for WD and AATD in 2027. 8️⃣ Over 70% of known genetic diseases are caused by mutations theoretically addressable by gene editing. 9️⃣ CRISPR edits happen in minutes to hours, but the therapeutic effect can last a lifetime. 🔟 Neoepitopes (rare/toxic protein fragments) from CRISPR 1.0 editing should be transient, not permanent. A steroid bridge should help mitigate this risk in weeks 3-5. 1️⃣1️⃣ The liver can regenerate even after ~70% tissue loss — one reason it’s a prime target for gene editing. 1️⃣2️⃣ Hereditary Angioedema (HAE) may become the first FDA approved cure by in vivo CRISPR in Q2 2027. 1️⃣3️⃣ CRISPR therapies can turn genes off, not just fix broken ones — useful when the gene itself is harmful. 1️⃣4️⃣ Gene editing can permanently lower cholesterol by targeting PCSK9, mimicking rare “super-healthy” humans. 1️⃣5️⃣ Some people naturally have “gene-edited” phenotypes due to protective mutations — CRISPR copies nature. 1️⃣6️⃣ Editing efficiency in humans can exceed 90% in target cells, rivaling traditional drugs. 1️⃣7️⃣ Unlike gene therapy, gene editing does not rely on permanent foreign gene expression. 1️⃣8️⃣ Many CRISPR therapies use mRNA, meaning the editing machinery disappears after doing its job. 1️⃣9️⃣ Gene editing is already in the clinic for heart disease, liver disease, cancer, autoimmune disease, and more. It also has the potential for many other applications (CF, ocular, neurological etc). 2️⃣0️⃣ CRISPR was discovered in yogurt bacteria used by food companies. 2️⃣1️⃣ The 2020 Nobel Prize in Chemistry was awarded for CRISPR — one of the fastest Nobel recognitions ever. 2️⃣2️⃣ In vivo gene editing is closer to surgery than pharmacology: intervene once, then walk away. 2️⃣3️⃣ Editing a single gene can eliminate the need for lifelong injections costing hundreds of thousands per year. 2️⃣4️⃣ David Liu is known as the father of base editing (Nicole Gaudelli, Alexis Komor) and prime editing (Andrew Anzalone). 2️⃣5️⃣ We are likely witnessing the birth of a new medical pillar, alongside drugs, biologics, and surgery.

$ondo $glm $people %3.31 $grlc $ordi $xrp $fun $dodo $aioz $ens $pyth $trias $ar $vet $ada 01 $floki %2.29 $crv %2.29 %4.47 %3.40 $beam $bnb $mog $ondo $token $imx $rio %6.18 $lunc $sponge $trump

$aioz $xrp %1.25 $bnb $beam $ar $ada %4.45 $pyth $ens %5.07 $grlc $ondo $floki $ordi $crv $ethfi $glm $people $ondo $token %4.01 $fun $dodo %0.73 01 $vet $imx $mog $lunc $sponge %4.61 $rio $trias $trump